Rayford Steele (Nicolas Cage) is a pilot and lives in New York with his family. His daughter Chloe (Cassi Thomson) insists him to be with the family on his birthday but he has to go for a flight. He takes charge of the flight 257 bound to London from New York and the flight takes off on time. Chloe feels sad and takes her brother to a shopping mall. Suddenly her brother disappears while his clothes are left there. Similarly many people disappear in the mall and this creates a big confusion there. This causes traffic congestion and the streets end up in chaos.

Amidst this, even some of the flight passengers go missing. Rayford's co-pilot also disappears but his clothes are left there. Shocked to see this, he turns the flight back to New York but he is not able to land the flight safely due to signal problem. When he gets a chance to contact the ground officers, he explains the calamity but comes to know that it is happening everywhere. Moreover he is not able to get a runway to land the plane. While thinking about the safety of the passengers, his flight is hit by another flight causing damage to the wings. How he saves his passengers in this critical position is seen in the rest of the screenplay.

Nicolas has done his part well as a responsible pilot and an affectionate father. Cassi Thomson as his daughter looks beautiful and has displayed good acting as well. Background music and visual effects are an added strength to the movie. Director Vic Armstrong can be given special credit for giving a mysterious story with sentiment but the reasoning for the happenings is not satisfactory.