A bunch of youngsters keep getting disappeared mysteriously. On the other side Subbu Panju and Anu Krishna are in love with each other. The latter's father is a big shot and owns a rice mill at their hometown. The local gangster keeps locking horns with him as he wants to own the rice mill. This leads to a huge standoff between the two. 

Subbu then decides to intervene and help his lover' father out by initiating a fight with the gangster. The plan  backfires, and Subbu ends up injured badly and is hospitalised. Situation gets serious, and the dean of the hospital Ghazali injects him with a special type of medicine. Soon, Subbu heals with inhuman speed and wakes up with super power abilities. 

The rest of the plot revolves around finding out what was he injected with, whats the connection between the medicine and the missing youngsters, how is he going to reverse the situation, and what happens to the love between Subbu and Anu Krishna.

Both the film's leads; Subbu Panju and Anu Krishna has delivered an average performance. But at times the latter's performance is way too dramatic. Ghazali has directed the film and has also played a pivotal role. Though his idea of making a medical science fiction film seems interesting, he completely fails in the directorial department, as he falters with the screenplay and has delivered a poor quality film. 

In the other hand, Ghazali has done mediocre job as a supporting actor. Vignesh has provided the tunes for the film, and both his background scores and the songs are average. Agaran, Pothigai Rajan and Shiva has handled the cinematography department and their shots are decent. 

In short, Manusana Nee, is below average.